Table 1.

Differentially regulated genes involved in the valine degradation pathway

				Fold Change
Type	Symbol	Gene Name	Member of	d3	d5	d7
Enzyme	BCAT2*†	Branched-chain amino acid transaminase 2	Branched-chain amino acid transaminase	0.48	0.51	0.51
	BCKDHA	Branched-chain keto acid dehydrogenase E1, α-polypeptide	2-Oxoisovalerate dehydrogenase	0.38	0.38	0.39
	BCKDHB	Branched-chain keto acid dehydrogenase E1, β-polypeptide		0.35	0.36	0.38
	DBT	Dihydrolipoamide branched-chain transacylase E2		0.46	0.48	0.49
	DLD*	Dihydrolipoamide dehydrogenase		0.36	0.42	0.43
	AUH*†	AU RNA binding protein/enoyl-CoA hydratase	Enoyl-CoA hydratase	0.35	0.40	0.38
	EHHADH*	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase		0.49	0.46	0.42
	HADHA*	Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, α-subunit		0.51	0.52	0.49
	HADHB*	Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, β-subunit		0.34	0.37	0.35
	HIBCH	3-Hydroxyisobutyryl-CoA hydrolase	3-Hydroxyisobutyryl-CoA hydrolase	0.40	0.42	0.43
	HIBADH	3-Hydroxyisobutyrate dehydrogenase	3-Hydroxyisobutyryl-CoA dehydrogenase	0.47	0.50	0.49

The nos. represent the fold change of gene expression after 3, 5 and 7 days (d3, d5, d7, respectively) of mechanical overload compared with control non-overloaded muscles. Italicized numbers mean that the fold change in gene expression is lower than 50% decrease. The selected genes were differentially expressed (twofold increase or 50% decrease) at least one time between d3 and d7.

^*Genes also associated with the isoleucine degradation pathway.

^†Genes also associated with the leucine degradation pathway.