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Cardiac growth in response to β-pageer treatment in Y and A mice. A: the nonselective β-AR antagonist carvedilol (Car) blocks pathological cardiac growth in response to ISO in A but not Y mice. The selective β1-AR antagonists, metoprolol (Met; B), bisoprolol (Bis; C), nebivolol (Neb; D), and CGP-20712A (CGP; E) block cardiac growth in response to ISO in both Y and A mice. Values are means ± SE. *P < 0.05, †P < 0.01, ‡P < 0.0005.
