Figure 2.

F, haplotype block size and F_st with the Luhya people in relation to the PCs. For the first three PCs (a–c, respectively), the Dutch subjects were ordered in an ascending order according to their PC value (=PCs from Panel 3, the LD-pruned dataset without long-range LD regions) and divided into 10 equally sized groups (the first 9 groups with N=444, and group 10 with N=445). For each of the 10 groups, the mean F (inbreeding coefficient) is calculated and plotted with its 95% confidence interval. As an illustration of two related measures, the genome-wide average haplotype block size and the mean F_st with the Luhya people from 1000 Genomes, are plotted as well.