Figure 1.

Cellular transporters involved in signal dependent nuclear targeting of herpesviral proteins. Transport of cargoes across the nuclear envelope (NE) occurs exclusively through channels delimited by the nuclear pore complexes (NPCs), upon recognition of specific nuclear localization complexes (NLSs) by specialized cellular transporters, with different signals being recognized by a variety of transporters: the IMPα/β1 heterodimer recognizes cNLSs, which can either be of the monopartite or bipartite type (A), importin IMPβ1 recognizes arg-rich NLSs (B), whereas IMPβ2 recognizes PY‑NLSs. Proteins carrying the various types of NLS are listed in the boxes, with prototypical NLSs being shown in black, and herpesviral DNA replicase NLSs indicated in red.