Table 2. Result of Cox regression analysis for patients' features in those with NSCLC (n= 120 745).
| No. of patients (%) | No. of patients who died (%) | Unadjusted HR (95% CI) | Adjusted HRa (95% CI) | P-value | |
|---|---|---|---|---|---|
|
Year | |||||
| 2004/2005 | 15 267 (12.64) | 13 960 (91.44) | 1 | 1 | |
| 2006 | 15 525 (12.86) | 14 051 (90.51) | 1.00 (0.98–1.03) | 1.02 (0.99–1.04) | |
| 2007 | 18 193 (15.07) | 16 333 (89.78) | 1.03 (1.00–1.05) | 1.02 (1.00–1.04) | |
| 2008 | 21 860 (18.10) | 19 103 (87.39) | 1.03 (1.01–1.05) | 0.99 (0.97–1.01) | <0.001b |
| 2009 | 25 072 (20.76) | 20 667 (82.43) | 1.00 (0.98–1.02) | 0.95 (0.93–0.97) | |
| 2010 |
24 828 (20.56) |
18 090 (72.86) |
0.99 (0.97–1.02) |
0.98 (0.96–1.00) |
|
|
Sex | |||||
| Female | 51 366 (42.54) | 42 476 (82.69) | 1 | 1 | |
| Male |
69 379 (57.46) |
59 728 (86.09) |
1.10 (1.09–1.12) |
1.13 (1.12–1.14) |
<0.001 |
|
Age | |||||
| <54 | 8097 (6.71) | 6111 (75.47) | 1 | 1 | |
| 55–59 | 8672 (7.18) | 6935 (79.97) | 1.12 (1.08–1.16) | 1.12 (1.09–1.16) | |
| 60–64 | 14 342 (11.88) | 11 475 (80.01) | 1.15 (1.12–1.19) | 1.19 (1.16–1.23) | |
| 65–69 | 17 846 (14.78) | 14 511 (81.31) | 1.22 (1.18–1.25) | 1.25 (1.21–1.29) | |
| 70–74 | 20 715 (17.16) | 17 462 (84.30) | 1.35 (1.31–1.39) | 1.35 (1.31–1.39) | <0.001b |
| 75–79 | 21 897 (18.13) | 19 087 (87.17) | 1.51 (1.47–1.55) | 1.45 (1.40–1.49) | |
| 80–84 | 17 375 (14.39) | 15 658 (90.12) | 1.73 (1.68–1.79) | 1.55 (1.51–1.60) | |
| 85+ |
11 801 (9.77) |
10 965 (92.92) |
2.05 (1.99–2.11) |
1.62 (1.57–1.68) |
|
|
Stage | |||||
| IA–IB | 12 156 (10.07) | 6045 (49.73) | 1 | 1 | |
| IIA–IIB | 5836 (4.83) | 3751 (64.27) | 1.54 (1.48–1.60) | 1.54 (1.48–1.61) | |
| IIIA | 8789 (7.28) | 7042 (80.12) | 2.35 (2.27–2.43) | 2.33 (2.25–2.42) | |
| IIIB | 14 209 (11.77) | 12 754 (89.76) | 3.30 (3.20–3.40) | 3.20 (3.10–3.30) | <0.001b |
| IV | 38 546 (31.92) | 36 600 (94.95) | 5.27 (5.13–5.42) | 4.58 (4.45–4.71) | |
| Missing |
41 209 (34.13) |
36 012 (87.39) |
3.11 (3.03–3.20) |
2.78 (2.70–2.86) |
|
|
Performance status | |||||
| 0 | 16 984 (14.07) | 11 395 (67.09) | 1 | 1 | |
| 1 | 27 134 (22.47) | 21 775 (80.25) | 1.49 (1.45–1.52) | 1.28 (1.25–1.31) | |
| 2 | 17 963 (14.88) | 16 378 (91.18) | 2.43 (2.38–2.49) | 1.84 (1.80–1.89) | |
| 3 | 16 051 (13.29) | 15 462 (96.33) | 4.01 (3.92–4.11) | 2.72 (2.65–2.79) | <0.001b |
| 4 | 5320 (4.41) | 5228 (98.27) | 7.24 (7.00–7.48) | 4.39 (4.24–4.54) | |
| Missing |
37 293 (30.89) |
31 966 (85.72) |
1.83 (1.79–1.87) |
1.55 (1.52–1.59) |
|
|
Ethnicity | |||||
| White | 90 367 (74.84) | 76 992 (85.20) | 1 | 1 | |
| Black | 872 (0.72) | 688 (78.90) | 0.81 (0.75–0.88) | 0.80 (0.74–0.87) | |
| Asian | 1182 (0.98) | 892 (75.47) | 0.72 (0.68–0.77) | 0.68 (0.63–0.73) | |
| Mixed | 178 (0.15) | 142 (79.78) | 0.83 (0.71–0.98) | 0.88 (0.74–1.04) | <0.001c |
| Other | 673 (0.56) | 537 (79.79) | 0.86 (0.79–0.93) | 0.80 (0.73–0.87) | |
| Missing |
27 473 (22.75) |
22 953 (83.55) |
1.06 (1.05–1.08) |
1.08 (1.06–1.10) |
|
|
Charlson index | |||||
| 0 | 47 870 (39.65) | 38 513 (80.45) | 1 | 1 | |
| 1 | 23 992 (19.87) | 19 806 (82.55) | 1.06 (1.05–1.08) | 1.00 (0.99–1.02) | |
| 2 & 3 | 20 319 (16.83) | 17 046 (83.89) | 1.14 (1.12–1.16) | 1.01 (0.99–1.03) | <0.001b |
| 4+ |
28 564 (23.66) |
26 839 (93.96) |
2.03 (2.00–2.06) |
1.53 (1.50–1.55) |
|
|
Source of referral | |||||
| Referral from GP | 57 864 (47.92) | 47 234 (81.63) | 1 | 1 | |
| Emergency admission | 15 399 (12.75) | 14 557 (94.53) | 2.19 (2.15–2.23) | 1.53 (1.50–1.56) | |
| Domiciliary visit | 319 (0.26) | 256 (80.25) | 0.96 (0.85–1.09) | 0.97 (0.86–1.10) | |
| Ref. from consultant | 23 385 (19.37) | 19 476 (83.28) | 1.16 (1.14–1.18) | 1.05 (1.03–1.06) | |
| Self-referral | 174 (0.14) | 146 (83.91) | 1.11 (0.94–1.30) | 0.98 (0.83–1.15) | |
| Other (private health care) | 8289 (6.86) | 6877 (82.97) | 1.08 (1.05–1.10) | 0.99 (0.97–1.02) | <0.001c |
| Following A&E attendance | 7340 (6.08) | 6759 (92.08) | 1.94 (1.89–1.99) | 1.44 (1.40–1.48) | |
| General dental practice | 45 (0.04) | 44 (97.78) | 1.65 (1.23–2.22) | 1.46 (1.09–1.96) | |
| Community dental service | 8 (0.01) | 6 (75.00) | 1.00 (0.45–2.23) | 0.99 (0.44–2.20) | |
| Not known | 7922 (6.56) | 6849 (86.46) | 1.15 (1.12–1.18) | 1.07 (1.04–1.09) | |
Abbreviations: CI=confidence interval; HR=hazard ratio.
a
HR adjusted for all other variables in the table.
b
P-value for trends.
c
Log-likelihood ratio test.