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. Author manuscript; available in PMC: 2013 Oct 18.
Published in final edited form as: J Med Chem. 2012 Feb 22;55(5):2025–2034. doi: 10.1021/jm2011595

Table 1.

Antibacterial Activities of peptides and pseudopeptides minimal inhibitory concentration (MIC) expressed in μg.mL−1.

Cuttlefish peptide Analogs of cuttlefish peptide Antibiotics
AD AK 3K K-2Nal7 K-1Nal K-2Nal Ampicillin

Gram positive

Bacillus megaterium 640 80 na 80 20 80 20
Enterococcus faecalis naa na na >640 >640 >640 5
Listeria monocytogenes na na na 80 80 160 5
Staphylococcus aureus na 320 na 80 20 40 5

Gram negative

Escherichia coli 640 80 na 320 40 160 5
Salmonella typhimurium na 320 na 80 80 160 5
Pseudomonas aeruginosa na 640 >640 160 160 320 320
Klebsiella pneumoniae na >640 na na na >640 5

Vibrio harveyi >640 320 na 40 640 640 >320
Vibrio alginolyticus 320 320 na 80 >640 >640 >320
Vibrio aestuarianus 640 80 na 40 80 80 5
Vibrio splendidus 320 40 320 20 320 640 10
a

na : not active