Table 2. Parameters Obtained from Fits to Neutron Reflectivity Profiles Recorded for the Surface-Deposited 7:3 d-POPC/POPS, 85:15 d-POPC/CL, and 7:3 DOPC/DOPS Phospholipid Bilayers in the Presence of 4 μM d-α-Synucleina.
| outer acyl chain thinning (Å) | increased solvent content in outer acyl chain layer | protein volume fraction in outer headgroup layer (vol %) | lipid/protein (v/v) | lipid/protein (n/n) | |
|---|---|---|---|---|---|
| 7:3 d-POPC/POPS | 1 ± 0.5 | 14 ± 3 | 12 ± 4 | 5.0 ± 0.4 | 296 ± 24 |
| 85:15 d-POPC/CL | 1 ± 0.5 | 15 ± 2 | 14 ± 3 | 3.9 ± 0.3 | 198 ± 15 |
| 7:3 DOPC/DOPS | 1 ± 0.5 | 5 ± 3 | 23 ± 5 | 2.3 ± 0.3 | 136 ± 18 |
a
See Methods and Table S2 of the Supporting Information for further details of the fitting procedure and error analysis.