Table 1.
Target genes regulated after ABT-737 treatment of AML mice
| Gene symbol | Regulation | Fold change | P value | Entrez gene ID |
|---|---|---|---|---|
| Proliferation related genes downregulated | ||||
| Myc | Down | 2.08 | 3.89E-02 | 17869 |
| Mcm5 | Down | 1.64 | 2.31E-02 | 17218 |
| Mcm7 | Down | 1.53 | 4.95E-02 | 17220 |
| E2f1 | Down | 1.52 | 3.06E-02 | 13555 |
| Pole4 | Down | 1.65 | 1.36E-02 | 66979 |
| Myeloid differentiation genes upregulated | ||||
| Csf1 | Up | 1.80 | 2.24E-02 | 12977 |
| Cd14 | Up | 2.08 | 2.81E-02 | 12475 |
| Csf3r | Up | 3.36 | 2.40E-02 | 12986 |
| Itgb2 | Up | 1.89 | 2.33E-02 | 16414 |
| Itgb2l | Up | 3.51 | 3.55E-02 | 16415 |
| Rara | Up | 1.56 | 9.60E-03 | 19401 |
| Apoptosis related genes upregulated | ||||
| Tnfrsf23 | Up | 5.22 | 2.20E-03 | 79201 |
| Mapk13 | Up | 3.10 | 3.00E-02 | 26415 |
| Tnfrsf17 | Up | 2.17 | 3.66E-02 | 21935 |
| Card10 | Up | 1.67 | 3.17E-02 | 105844 |
| Ctsd | Up | 1.72 | 2.16E-02 | 13033 |
| Dapk2 | Up | 1.63 | 3.07E-02 | 13143 |
| Capn2 | Up | 1.62 | 4.03E-02 | 12334 |
| Dapk1 | Up | 1.54 | 3.06E-02 | 69635 |
| Nfkbiz | Up | 1.53 | 6.20E-03 | 80859 |
| Cox4i2 | Up | 1.53 | 2.12E-02 | 84682 |
| Parp4 | Up | 1.51 | 1.78E-03 | 328417 |
| Stem cells related upregulated | ||||
| Tcf7l2 | Up | 2.13 | 3.38E-02 | 21416 |
| Piwil2 | Up | 2.20 | 3.06E-02 | 57746 |
| Bmpr1a | Up | 2.31 | 4.63E-02 | 12166 |
| Spp1 | Up | 4.32 | 1.38E-0.2 | 20750 |
Fold change of treated compared with untreated mice was considered significant when ≥1.5 and P value ≤ .05. The arrays were normalized to FVB/N, and then the treated was compared with the untreated group (n=3) (GEO accession no. GSE48601).