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ClockΔ19 mice exhibit augmented responses to the sedative effects of ethanol and ketamine. Latency (a) and duration (b) to ethanol-induced loss of righting reflex (LORR) at ZT5 and ZT11. Latency (c) and duration (d) to ketamine-induced LORR. Latency (e) and duration (f) to pentobarbitol-induced LORR. *p<0.05; ***p<0.001. WT, wild type; ZT, zeitgeber time.
