Figure 4.

Effects of intra-CeA injection of rimonabant (30 min pretreatment, 0, 0.5, 1.5 μg/side) on anxiety-like behavior and food intake in diet-cycled female Wistar rats (n=46). (a) Rimonabant, microinfused within the CeA during the 4th day of withdrawal from palatable food (C Phase), selectively precipitates anxiety-like behavior, measured using an elevated plus-maze test, in Chow/Palatable rats. (Top panels) % open arm time, a measure of anxiety-like behavior; (bottom panels) number of closed arm entries, a measure of locomotor activity. (b) Rimonabant, microinfused into the CeA during the 4th day of withdrawal from palatable food (C Phase), selectively precipitates chow anorexia; in contrast, microinfusion during the 6th day (P Phase), does not affect intake of the highly palatable diet in Chow/Palatable rats. (c) Drawing of coronal rats' brain slices. Dots represent the injection sites in the CeA included in the data analysis. Panels represent M±SEM. Symbols denote: *significant difference from vehicle condition p<0.05, **p<0.01.