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Characterization of FGFR4 binding scaffolds. (A) IgG, F(ab)2, and Fab constructs bind specifically to FGFR4. (B) In an FGF19 competition ELISA, all constructs compete with FGF19 to bind to FGFR4. (C) All constructs bind to Huh-7 cells. (D) PK curves of IgG, F(ab)2, and Fab following a single i.v. dose of 10 mg/kg in Swiss Webster mice. Both total and FGFR4 binding were measured as described in the Materials and Methods section.
