Fig. 12.

Crystal structure of the binding pocket of MOR-1 with β-funaltrexamine. The crystal structure of MOR-1 was determined with β-funaltrexamine covalently attached within the binding pocket. The left is a side view of the structure with a “transection” of the receptor to show the docking of the ligand. The view on the right is looking at the docking of the ligand from the extracellular surface. Reprinted by permission from Macmillan Publishers Ltd: [Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, and Granier S (2012) Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature 485:321–326].