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. 2013 Oct;65(4):1257–1317. doi: 10.1124/pr.112.007138

Fig. 19.

Fig. 19.

Schematic of the OPRM1 gene promoters in mice. Exons 11 and 1 are indicated by black boxes. The 5′-flanking regions and defined promoter regions are shown by lines. Transcription start points (tsp) and translation start codon (ATG) are indicated by arrows. Cis-acting elements that bind to corresponding trans-acting factors are shown by boxes of various shapes/colors along the promoter regions. TATA, TATA-binding protein; AP-1, activator protein 1; AP-2, activator protein 2; CCAAT, CCAAT box binding factors; C/EBP, CCAAT/enhancer-binding proteins; cMyc/Max, cMyc and Max factors; NRSE, neurorestrictive silencer element; Oct-1, octamer-1; Sp1, specificity protein 1; Sp3, specificity protein 3; CRE, cyclic adenosine monophosphate (cAMP) response element binding protein; 34 bp, 34-bp element; Sox, Sry-like high-mobility-group box gene; PARP1, poly(ADP-ribose polymerase 1; PCBP, polyC-binding protein; STAT1, signal transducers and activators of transcription type 1.