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Opioid binding to multiple mu and delta sites in brain
As shown, mu1 sites have very high affinity for both mu and most delta ligands, whereas mu2 and delta sites are selective. Adapted from Wolozin and Pasternak (1981).
| Approximate KD Values |
|||
|---|---|---|---|
| Mu1 | Mu2 | Delta | |
| nM | |||
| Morphine | |||
| Saturation studies | 0.4 | 11 | — |
| Competition studies | <1 | 8 | 71 |
| [d-Ala2,d-Leu5]Enkephalin | |||
| Saturation studies | 0.5 | — | 5 |
| Competition studies | <1 | 50 | 8 |
