TABLE 11.

Naloxonazine-sensitive and -insensitive actions

Compiled from the literature (Pasternak et al., 1980b, 1983; Hahn and Pasternak, 1982; Ling et al., 1983, 1984, 1985, 1986; Munson, 1983; Wood and Pasternak, 1983; Bodnar et al., 1988; Heyman et al., 1988; Mann et al., 1988a,b; Paul and Pasternak, 1988; Paul et al., 1989a; Janik et al., 1992; Pick et al., 1993; Honkanen et al., 1996).

Morphine Effect	Sensitivity
	β-Funaltrexamine	Naloxonazine
Analgesia
Systemic	Yes	Yes
Supraspinal	Yes	Yes
Spinal	Yes	No
Supraspinal/spinal synergy	Yes	No
Respiratory depression	Yes	No
Inhibition of gastrointestinal transit	Yes	No
Prolactin release	Yes	Yes
Growth hormone release	Yes	No
Physical dependence	Yes	Mixed
Feeding	Yes	Yes
Nigrostriatal dopamine release		No
Alcohol intake		Yes
Pruritus		No