TABLE 14.

Amino acid sequences resulting from 5′ splicing of OPRM1

The exon 11 sequences are immediately upstream of exon 2, as noted. The N-terminal fusion sequences exon 11-associated splice variants are found in the rat and human variants, as noted. In the human variant hMOR-1i, translation is initiated at the AUG at the beginning of exon 1c, which encodes 49 aa,and the proceeds through exon 1a, with an additional 44 aa generated by the exon 1a sequence immediately upstream of the AUG used to initiate translation in MOR-1. In the rat variant rMOR-1H2, the additional sequence comes from exon 11a, which is joined to exon 1. Translation in the full exon 11a/b leads to a truncated protein corresponding to only the first 7 aa shown for exon 11a alone. The * designates the termination of translation due to a stop codon, and the indicated peptide is the complete product.

Species	Exon	Variant	Amino Acid Sequence
Exon 11 sequences
Mouse	Exon 11	mMOR-1G/M/N	MMEAFSKSAFQKLRQRDGNQEGKSYLR
Human	Exon 11a/b	hMOR-1G1	MMRAKSISTKAGKPSRFIWKKILL*
	Exon 11a	hMOR-1G2	MMRAKSISTKAGKPSR
Rat	Exon 11a	rMOR-1G2	MGSGPML
	Exon 11a/b	rMOR-1G1	MGSGPML*
N-terminal fusion sequences
Human	Exon 1c/a	hMOR-1i	MCLHRRVPSEETYSLDRFAQNPPLFPPPSLPASESRMAHAPLLQRCGAARTGFCKKQQELWQRRKEAAEALGTRKVSVLLATSHSGARPAVST
Rat	Exon 11a	rMOR-1H2	MGSGPMLAGPCKNLTEPRAAVRGRGWGAWNPKSLSALSYSLPSPQQAFST