TABLE 17.
Opioid analgesia in an exon 11 MOR-1 knockout mouse
Analgesia was assessed in either wild-type C57 (WT C57) or in mice with a disruption of exon 11 (exon 11 KO). Results (means ± S.E.M. of independent determinations) are from the literature (Pan et al., 2009; Majumdar et al., 2011).
| Drug | Analgesic ED50 |
Shift | |
|---|---|---|---|
| WT C57 | Exon 11 KO | ||
| mg/kg | |||
| Morphine | 1.58 ± 0.17 | 2.6 ± 0.5 | 1.6 |
| Methadone | 1.53 ± 0.06 | 1.8 ± 0.14 | 1.2 |
| IBNtxA | 0.53 ± 0.07 | > 20 | >35 |
| NalBzoH | 22 ± 5.3 | >100 | >5 |
| Nalbuphine | 47 ± 15 | >200 | >4 |
| Levorphanol | 0.1 ± 0.01 | 0.72 ± 0.13 | 7 |
| Butorphanol | 5.9 ± 3.9 | >100 | >15 |