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Morphine spinal/supraspinal synergy in rats
Morphine analgesia was assessed with either administration supraspinally, spinally, or simultaneously in both regions in a 1:1 ratio. Adapted from Yeung and Rudy (1980).
| Morphine ED50 |
||
|---|---|---|
| Supraspinal | Spinal | |
| μg | ||
| Each site alone | 10 | 4.2 |
| Both sites simultaneously | 0.35 | 0.35 |
