Fig. 6.

Degeneration of photoreceptor cells prevents the diabetes-induced production of proinflammatory enzymes in retina. Expression of iNOS and ICAM-1 were measured by Western blots in retinal tissue of wild-type control and diabetic mice, and in opsin^−/− N and D mice. Data are expressed relative to the expression of actin, a housekeeping protein in the same lanes, and are expressed as a percent of the value of nondiabetic wild-type controls. Duration of diabetes was 2 mo (n = 3–5 animals per group, 4 mo of age when killed).