Fig. 2.

HIF1α cKO mice are resistant to ovariectomy-induced bone loss and osteoclast activation. (A and B) BMD of femurs divided equally longitudinally from Sham or Ovx control (Hif1α^f/f) and HIF1α cKO (Ctsk^Cre/+; Hif1α^f/f) mice. (C) ES/BS of femurs from sham-operated or ovariectomized control and HIF1α cKO mice. (D) Levels of serum CTx, a marker of bone resorption, in control and HIF1α cKO mice. Analysis was undertaken 5 wk after Ovx or Sham surgery. All data are means ± SD (n = 5). *P < 0.05; **P < 0.01; ***P < 0.005; NS, not significant.