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. 2013 Sep 19;110(41):16550–16555. doi: 10.1073/pnas.1310215110

Fig. 4.

Fig. 4.

NKG2D-independent attenuation and immune function of RAE-1γ. (A) BALB/c mice were infected i.v. with 2 × 105 pfu per mouse of the indicated viruses. One day before infection and on days 2 and 5 p.i., mice were treated with αNKG2D antibody. Virus titer was determined on day 8 p.i. (B) Mice were infected with 105 pfu per mouse via f.p. and treated with αNKG2D as in A. LLO-specific CD8 T-cell response was determined on day 8 p.i. (n = 5). (C) C57BL/6 mice were infected with 2 × 105 pfu per mouse i.v. and treated with αNKG2D. The frequency of SIINFEKL-specific CD8 T cells was determined on day 8 p.i. (n = 3–4). (D) C57BL/6 and NKG2D−/− mice were infected i.v. with 2 × 105 pfu per mouse. On day 7 p.i., virus titer is shown. (E) The frequency of SIINFEKL-specific CD8 T cells was determined on day 7 p.i. (n = 3–4). (F) Virus titer in organs was determined on day 7 p.i. For A, D, and F, individual animals and median values are shown. For B, C, and E, mean ± SEM is shown.