Table 1.
Genes and functions of selected loci that are differentially essential in V. cholerae and E. coli
| Essential homolog in V. cholerae | Neutral homolog in V. cholerae | Homolog in E. coli | Essential In E. coli? | Annotated function |
|---|---|---|---|---|
| vc0631 | vc0465 | tyrS | Yes | Tyrosyl tRNA synthetase |
| vc2024 | vc0093 | plsB | Yes | Glycerol 3 phosphate acyltransferase |
| vc0743, vca0693 | secD | Yes | General secretion pathway translocase | |
| vc2269, vc1263 | ribA | Yes | GTP cylclohydrolase subunit II | |
| vc2269, vca1060 | ribB | Yes | 3,4 dihydroxy-2-butanone 4-phoshate synthase | |
| vc2107, vc2036 | asd | Yes | Aspartate semialdehyde dehydrogenase | |
| vc0058, vc0586, vca0274 | can | Yes | Carbonic anhydrase | |
| vc0046, vca0150 | def | Yes | Peptide deformylase | |
| vc2268 | ribE | Yes | Riboflavin synthase beta subunit | |
| vc2270 | ribC | Yes | Riboflavin synthase alpha subunit | |
| vc2271 | ribD | Yes | Riboflavin-specific deaminase | |
| vc1714-vc1716 | mukBEF | Yes | Condensin subunits BEF | |
| vc2626 | dam | No | Adenine Methyltransferase | |
| vc2763-vc2767 | atpCDGAH | No | F1 ATP synthase (ε,β,γ,α,δ) subunits | |
| vc2768-vc2770 | atpFEB | No | F0 ATP synthase (B,C,A) subunits |