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. 2013 Aug 5;41(19):9077–9089. doi: 10.1093/nar/gkt674

Figure 8.

Figure 8.

Structures of various RB69pol complexes. (A) Superposition of the structure of wt RB69pol closed ternary complex (PDB: 3NCI, shown in blue) with the structure of the binary complex in an editing mode (PDB: 1CLQ, shown in gray). The red arrow points to L415. (B) Shifting of P/T from pol to exo domain in wt RB69pol. The template strand in the pol domain is shown in cyan; the primer strand in the pol domain is shown in green. The template strand in the exo domain is shown in red; the primer strand in the exo domain is shown in blue. The exo domain is shown in yellow. (C) Superposition of the structures of all three L415 variants with that of wt RB69pol. Side chains in the structures of wt, L415M, L415A, L415G are shown in gray, blue, red and green, respectively. (D) A different view of C with emphasis on the interactions between T622 and the hydrogen bonding network located at the minor groove of the P/T junction.