Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Aug 24;41(19):e185. doi: 10.1093/nar/gkt753

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 3. — Characterization of the DNMT1 assay and inhibition studies on reference compounds. (A) Determination of SAM K_m at 1.0 µM of hemimethylated Dup_1. (B) Determination of DNA K_m at 15 µM of [methyl-³H] SAM. (C) Two independent dose-response curves for zebularine-containing duplex, each in duplicates. (D) Two independent dose-response curves for sinefungin, each in duplicates. (E) Two independent dose-response curves for 47, each in duplicates. K_m and coefficient of determination (R²) are displayed. Means of IC₅₀ and coefficient of determination (R²) are displayed.