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. 2013 Aug 24;41(19):e185. doi: 10.1093/nar/gkt753

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — DNA-competition assays on DNMT1 with sinefungin, zebularine-containing duplex and compound 47. Experiments with sinefungin are represented by open diamonds, zebularine-containing duplex by plain triangles and compound 47 by plain squares. (A and B) IC₅₀ of each molecule as function of [DNA]/. (C and D) as function of [inhibitor]. (E and F) 1/ as function of [inhibitor]. (G and H) 1/ as function of [inhibitor]. For each linear regression, if the slope is significantly different from 0, then the regression is represented by a plain line, and the coefficient of determination (R²) is displayed along the corresponding line.

Inline graphic — DNA-competition assays on DNMT1 with sinefungin, zebularine-containing duplex and compound 47. Experiments with sinefungin are represented by open diamonds, zebularine-containing duplex by plain triangles and compound 47 by plain squares. (A and B) IC₅₀ of each molecule as function of [DNA]/. (C and D) as function of [inhibitor]. (E and F) 1/ as function of [inhibitor]. (G and H) 1/ as function of [inhibitor]. For each linear regression, if the slope is significantly different from 0, then the regression is represented by a plain line, and the coefficient of determination (R²) is displayed along the corresponding line.