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. 2013 Jul 16;5(9):1322–1334. doi: 10.1002/emmm.201302507

Figure 1. ZIP4 induces the expression of miR-373 in pancreatic cancer.

Figure 1

  • A. Numerous microRNAs are differentially expressed in ZIP4 overexpressing and silencing cells and xenografts. A heat-map is shown in which colours represent relative levels of microRNAs with the brightest red indicating those with the highest ratio and green depicting the lowest ratio for the indicated comparisons. Lane 1: MIA-ZIP4 versus MIA-V cells; lane 2: AsPC-shZIP4 versus AsPC-shV cells; lane 3 and 4: AsPC-shZIP4 versus AsPC-shV xenografts #1 and #2.
  • B–D. miR-373 expression in (B) MIA-ZIP4 cells, (C) AsPC-shZIP4 cells, and (D) AsPC-shZIP4 orthotopic xenografts (P < 0.0001, t-test, n = 3). Data were expressed as the mean ± SD of triplicate values.