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. 2012 Dec 7;14(6):e169. doi: 10.2196/jmir.2319

Table 2.

AGREE II mean item scores and domain percentage scores for each guideline.

Item Guidelinea Overall mean score


NCPIC IPS NICE APA NSWD NSWP NHC
Scope and purpose, mean item score








Objective described 5.75 3.50 6.50 6.00 6.50 6.25 6.50 5.86

Health question described 6.00 4.25 6.50 6.25 6.25 6.50 5.50 5.89

Population described 6.00 4.50 6.50 5.75 5.75 6.50 6.25 5.89

Domain score,b % 82% 51% 92% 83% 86% 90% 85% 81%
Stakeholder involvement, mean item score








Relevant professional groups 5.25 2.25 6.50 3.75 5.00 5.75 5.00 4.79

Target population preferences 2.75 1.00 5.50 1.25 1.75 1.75 3.75 2.54

Target users defined 6.75 3.00 6.25 5.75 6.75 6.25 5.50 5.75

Domain score,b % 65% 18% 85% 43% 58% 60% 63% 56%
Rigor of development, mean item score








Systematic search 2.25 1.25 6.75 6.75 2.25 5.50 1.50 3.75

Selection criteria described 3.75 1.50 6.75 6.25 2.25 4.50 4.25 4.18

Strengths/limitations described 5.00 1.00 6.75 6.25 5.50 5.75 2.00 4.61

Formulation methods described 5.25 1.50 6.75 6.00 5.50 3.75 1.75 4.36

Risks/benefits considered 4.75 1.00 5.25 5.00 4.75 5.00 3.00 4.11

Suggestions linked to evidence 5.50 3.50 6.75 6.50 6.25 6.25 4.00 5.54

Externally reviewed by experts 1.00 1.00 5.00 5.00 1.25 1.75 1.25 2.32

Procedure for updates 3.50 1.00 6.50 5.00 4.50 1.75 1.25 3.36

Domain score,b % 48% 9% 89% 81% 51% 55% 23% 50%
Clarity of presentation, mean item score








Specific recommendations 6.25 4.00 6.50 5.50 5.75 5.25 4.50 5.39

Options presented 6.50 3.50 6.50 6.50 6.25 6.25 4.00 5.64

Identifiable recommendations 6.25 4.00 4.50 3.25 6.50 4.75 6.25 5.07

Domain score,b % 89% 47% 81% 68% 86% 74% 65% 73%
Applicability, mean item score








Facilitators/barriers described 4.75 1.25 3.75 4.75 3.75 3.25 3.00 3.50

Advice/tools for implementation 6.50 2.00 6.00 3.25 4.25 6.00 4.00 4.57

Resource implications considered 3.25 1.00 6.75 4.00 3.00 3.00 1.50 3.21

Monitoring criteria presented 4.00 2.00 5.25 4.25 4.00 4.25 3.50 3.89

Domain score,b % 60% 9% 74% 51% 46% 52% 33% 46%
Editorial independence, mean item score








Lack of funding body influence 4.25 1.00 4.50 3.50 3.75 3.50 1.50 3.14

Competing interests addressed 1.25 1.00 6.75 5.25 1.00 1.00 1.00 2.46

Domain score,b % 29% 0% 77% 56% 23% 21% 4% 30%
Overall guideline assessment, mean item score








Overall quality 5.50 2.00 6.00 4.75 4.50 5.25 3.50 4.50

a NCPIC: National Cannabis Prevention and Information Centre; IPS: Indian Psychiatric Society; NICE: National Institute for Health and Clinical Excellence; APA: American Psychiatric Association; NSWD: New South Wales-Drug; NSWP: New South Wales-Pregnancy; and NHC: National Health Committee.

b Domain percentage scores were derived by summing all mean individual AGREE II item scores and standardizing the total as a percentage of the maximum possible score for that domain.