Table 3.
MiRNAs called differentially expressed by next-generation sequencing
| miRNA | Control | LOAD | Fold Change | log2 Fold Change | pval | padj |
|---|---|---|---|---|---|---|
| hsa-miR-885-3p | 340 | 75 | 0.22 | −2.19 | 4.30E-20 | 3.61E-17 |
| hsa-miR-132-3p | 10,811 | 2513 | 0.23 | −2.10 | 2.01E-17 | 8.42E-15 |
| hsa-miR-132-5p | 1315 | 339 | 0.26 | −1.95 | 6.97E-13 | 1.95E-10 |
| hsa-miR-3607-3p | 3946 | 576 | 0.15 | −2.78 | 1.08E-12 | 2.27E-10 |
| hsa-miR-1225-3p | 135 | 27 | 0.20 | −2.35 | 1.04E-11 | 1.74E-09 |
| hsa-miR-153 | 4341 | 12,623 | 2.91 | 1.54 | 1.41E-11 | 1.97E-09 |
| hsa-miR-323a-3p | 6852 | 2640 | 0.39 | −1.38 | 3.85E-11 | 4.61E-09 |
| hsa-miR-212-3p | 740 | 215 | 0.29 | −1.78 | 2.89E-10 | 3.04E-08 |
| hsa-miR-504 | 1353 | 540 | 0.40 | −1.33 | 4.24E-10 | 3.95E-08 |
| hsa-miR-7-1-3p | 166 | 432 | 2.60 | 1.38 | 6.46E-10 | 5.42E-08 |
| hsa-miR-5701 | 217 | 46 | 0.21 | −2.25 | 8.31E-10 | 6.34E-08 |
| hsa-miR-338-3p | 28,741 | 65,927 | 2.29 | 1.20 | 9.47E-10 | 6.62E-08 |
| hsa-miR-26b-3p | 435 | 174 | 0.40 | −1.33 | 2.40E-09 | 1.55E-07 |
| hsa-miR-877-5p | 181 | 60 | 0.33 | −1.59 | 3.05E-09 | 1.83E-07 |
| hsa-miR-3653 | 226 | 51 | 0.23 | −2.14 | 8.27E-09 | 4.62E-07 |
| hsa-miR-212-5p | 197 | 51 | 0.26 | −1.94 | 9.04E-09 | 4.74E-07 |
| hsa-miR-150-5p | 4314 | 1951 | 0.45 | −1.14 | 1.05E-08 | 5.20E-07 |
| hsa-miR-488-3p | 535 | 1212 | 2.27 | 1.18 | 1.93E-08 | 9.02E-07 |
| hsa-miR-152 | 83 | 252 | 3.03 | 1.60 | 3.45E-08 | 1.52E-06 |
| hsa-miR-539-5p | 428 | 185 | 0.43 | −1.21 | 4.18E-08 | 1.69E-06 |
| hsa-miR-485-5p | 1270 | 572 | 0.45 | −1.15 | 4.22E-08 | 1.69E-06 |
| hsa-miR-301a-3p | 3613 | 7532 | 2.08 | 1.06 | 4.69E-08 | 1.71E-06 |
| hsa-miR-423-3p | 13,338 | 6057 | 0.45 | −1.14 | 4.52E-08 | 1.71E-06 |
| hsa-miR-340-5p | 38,252 | 19,537 | 0.51 | −0.97 | 6.67E-08 | 2.33E-06 |
| hsa-miR-323a-5p | 66 | 22 | 0.33 | −1.60 | 8.14E-08 | 2.73E-06 |
| hsa-miR-18a-5p | 81 | 215 | 2.65 | 1.41 | 1.60E-07 | 4.98E-06 |
| hsa-miR-330-5p | 1235 | 2588 | 2.10 | 1.07 | 1.60E-07 | 4.98E-06 |
| hsa-miR-208b | 33 | 90 | 2.71 | 1.44 | 1.68E-07 | 5.03E-06 |
| hsa-miR-487b | 8194 | 3884 | 0.47 | −1.08 | 2.05E-07 | 5.93E-06 |
| hsa-miR-32-5p | 189 | 417 | 2.20 | 1.14 | 2.56E-07 | 6.93E-06 |
| hsa-miR-767-5p | 563 | 253 | 0.45 | −1.15 | 2.53E-07 | 6.93E-06 |
| hsa-miR-6087 | 9 | 2 | 0.16 | −2.61 | 2.69E-07 | 7.05E-06 |
| hsa-miR-149-5p | 25,531 | 12,021 | 0.47 | −1.09 | 4.27E-07 | 1.09E-05 |
| hsa-miR-376a-5p | 3336 | 1156 | 0.35 | −1.53 | 5.02E-07 | 1.24E-05 |
| hsa-miR-142-5p | 1367 | 4387 | 3.21 | 1.68 | 5.28E-07 | 1.27E-05 |
| hsa-miR-516a-5p | 28 | 76 | 2.73 | 1.45 | 6.19E-07 | 1.44E-05 |
| hsa-miR-590-3p | 125 | 274 | 2.19 | 1.13 | 9.38E-07 | 2.13E-05 |
| hsa-miR-138-5p | 73,258 | 30,965 | 0.42 | −1.24 | 9.82E-07 | 2.17E-05 |
| hsa-miR-744-5p | 8825 | 4298 | 0.49 | −1.04 | 1.05E-06 | 2.26E-05 |
| hsa-miR-377-3p | 231 | 477 | 2.07 | 1.05 | 1.53E-06 | 3.21E-05 |
| hsa-miR-222-3p | 19,064 | 10,221 | 0.54 | −0.90 | 1.77E-06 | 3.62E-05 |
| hsa-let-7d-5p | 18,241 | 9963 | 0.55 | −0.87 | 2.52E-06 | 5.03E-05 |
| hsa-miR-301b | 398 | 792 | 1.99 | 0.99 | 2.69E-06 | 5.25E-05 |
| hsa-miR-374b-5p | 570 | 1429 | 2.51 | 1.33 | 3.31E-06 | 6.31E-05 |
| hsa-miR-194-5p | 320 | 634 | 1.98 | 0.98 | 4.17E-06 | 7.72E-05 |
| hsa-miR-370 | 864 | 397 | 0.46 | −1.12 | 4.23E-06 | 7.72E-05 |
| hsa-miR-1298 | 137 | 60 | 0.44 | −1.19 | 4.67E-06 | 8.34E-05 |
| hsa-miR-1225-5p | 42 | 12 | 0.28 | −1.83 | 5.25E-06 | 9.18E-05 |
| hsa-miR-873-3p | 531 | 244 | 0.46 | −1.12 | 5.49E-06 | 9.40E-05 |
| hsa-miR-708-5p | 948 | 1812 | 1.91 | 0.93 | 5.72E-06 | 9.59E-05 |
| hsa-miR-6511b-3p | 296 | 146 | 0.49 | −1.02 | 7.77E-06 | 0.0001 |
| hsa-miR-142-3p | 202 | 401 | 1.98 | 0.99 | 7.63E-06 | 0.0001 |
| hsa-miR-454-3p | 838 | 1583 | 1.89 | 0.92 | 9.10E-06 | 0.0001 |
| hsa-miR-374a-5p | 244 | 972 | 3.98 | 1.99 | 9.46E-06 | 0.0001 |
| hsa-miR-769-5p | 72,207 | 40,795 | 0.56 | −0.82 | 9.73E-06 | 0.0001 |
| hsa-miR-1180 | 1487 | 788 | 0.53 | −0.92 | 9.96E-06 | 0.0001 |
| hsa-miR-6511a-3p | 262 | 130 | 0.49 | −1.01 | 1.02E-05 | 0.0002 |
| hsa-miR-363-3p | 1570 | 2898 | 1.85 | 0.88 | 1.13E-05 | 0.0002 |
| hsa-miR-1276 | 19 | 6 | 0.28 | −1.81 | 1.21E-05 | 0.0002 |
| hsa-miR-365a-3p | 145 | 290 | 1.99 | 0.99 | 1.23E-05 | 0.0002 |
| hsa-miR-186-5p | 12,389 | 21,604 | 1.74 | 0.80 | 1.24E-05 | 0.0002 |
| hsa-miR-365b-3p | 195 | 380 | 1.95 | 0.97 | 1.30E-05 | 0.0002 |
| hsa-miR-339-3p | 2388 | 1192 | 0.50 | −1.00 | 1.29E-05 | 0.0002 |
| hsa-miR-223-3p | 324 | 664 | 2.05 | 1.04 | 1.35E-05 | 0.0002 |
| hsa-miR-146b-3p | 329 | 168 | 0.51 | −0.97 | 1.45E-05 | 0.0002 |
| hsa-miR-195-5p | 4050 | 7216 | 1.78 | 0.83 | 1.59E-05 | 0.0002 |
| hsa-miR-501-3p | 195 | 377 | 1.93 | 0.95 | 1.69E-05 | 0.0002 |
| hsa-miR-424-5p | 175 | 339 | 1.94 | 0.96 | 1.82E-05 | 0.0002 |
| hsa-miR-668 | 668 | 358 | 0.54 | −0.90 | 2.31E-05 | 0.0003 |
| hsa-miR-3613-5p | 143 | 278 | 1.95 | 0.96 | 2.42E-05 | 0.0003 |
| hsa-miR-574-3p | 739 | 1356 | 1.84 | 0.88 | 2.46E-05 | 0.0003 |
| hsa-miR-511 | 9 | 2 | 0.25 | −2.00 | 2.69E-05 | 0.0003 |
| hsa-miR-6721-5p | 8 | 2 | 0.24 | −2.03 | 3.12E-05 | 0.0004 |
| hsa-miR-4520a-3p | 15 | 4 | 0.29 | −1.80 | 3.53E-05 | 0.0004 |
| hsa-miR-409-3p | 7499 | 4337 | 0.58 | −0.79 | 4.07E-05 | 0.0005 |
| hsa-miR-1185-1-3p | 80 | 32 | 0.40 | −1.31 | 4.93E-05 | 0.0005 |
| hsa-miR-1307-3p | 1827 | 1025 | 0.56 | −0.83 | 5.14E-05 | 0.0006 |
| hsa-miR-17-5p | 672 | 1202 | 1.79 | 0.84 | 5.47E-05 | 0.0006 |
| hsa-miR-423-5p | 2621 | 1491 | 0.57 | −0.81 | 5.54E-05 | 0.0006 |
| hsa-miR-139-3p | 397 | 216 | 0.54 | −0.88 | 6.15E-05 | 0.0006 |
| hsa-miR-671-5p | 113 | 56 | 0.49 | −1.03 | 6.48E-05 | 0.0007 |
| hsa-miR-3613-3p | 18 | 44 | 2.44 | 1.28 | 7.18E-05 | 0.0007 |
| hsa-miR-148b-3p | 1211 | 4542 | 3.75 | 1.91 | 7.91E-05 | 0.0008 |
| hsa-miR-16-5p | 18,412 | 30,124 | 1.64 | 0.71 | 8.14E-05 | 0.0008 |
| hsa-miR-191-3p | 142 | 73 | 0.51 | −0.97 | 8.58E-05 | 0.0008 |
Control: normalized counts for the control group; LOAD: normalized counts for the LOAD group; pval: nominal p-value determined by the nbinomTest; padj: nominal p-value corrected for multiple testing by the BH procedure.