Figure 3.

Activation of NFκB transcription factors. Two signalling pathways control nuclear translocation of the dimeric transcription factors of the NFκB family: the classical and alternative NFκB pathway. Noteworthy, the proteins TRAF2, cIAP1 and cIAP2 act as positive mediators in the classical pathway but as inhibitors in the alternative pathway. Please be aware that there can be significant crosstalk between the two pathways in a cell type-specific manner by various mechanisms, including NIK-mediated activation of the IKK complex, inhibition of p65-p50 dimers by p100 and transcriptional upregulation of p100 and RelB via the classical pathway.