Table 1.

Therapeutic effects of Fn14 or TWEAK targeting proteins in preclinical models

Reagent	Model	Effect	Reference
Hamster anti-TWEAK	CIA	50% reduction in cumulative disease score Reduced synovial angiogenesis,	(Perper et al., 2006)
Rat anti-TWEAK	CIA	50% reduction in cumulative disease score Reduced synovial angiogenesis,	(Kamata et al., 2006)
anti-TWEAK	TNBS colitis	∼40% reduction in mean clinical score	(Dohi et al., 2009)
Fn14-TRAIL	EAE	∼50% reduction in mean clinical score, superior to side by side treatment with Fn14-Fc and TRAIL	(Razmara et al., 2009)
anti-TWEAK	EAE	∼40–80% reduction in mean clinical score	(Desplat-Jego et al., 2005)
TWEAK vaccination	EAE	∼20–60% reduction in mean clinical score	(Mueller et al., 2005)
anti-TWEAK	MACO	∼20% reduction in mean infarct size	(Potrovita et al., 2004)
Fn14-Fc	MACO	∼33% reduction in mean infarct size	(Yepes et al., 2005)
Fn14-Fc	MACO	∼70% inhibition of MACO-induced BBB leakiness	(Polavarapu et al., 2005)
Fn14-Fc	MACO	∼75% inhibition of MACO-induced BBB leakiness ∼50% reduction in mean infarct size	(Zhang et al., 2007)
TWEAK	MACO	∼33% reduction in MACO-induced mean infarct size by TWEAK pretreatment	(Echeverry et al., 2012)
anti-TWEAK	Denervation induced muscle atrophy	Less reduction in muscle fibre cross section area	(Mittal et al., 2010a)
anti-TWEAK	atherosclerosis	Reduced renal damage (∼50%) Reduced RANTES and MCP1 expression in atherosclerotic plaques and kidney (>50%)	(Munoz-Garcia et al., 2009)
Fn14-Fc	atherosclerosis	Attenuated plaque progression Reduced collagen deposition in advance plaques	(Schapira et al., 2009)
anti-TWEAK	NTN	>80% reduction in proteinuria Reduced expression of MCP-1, RANTES, IP-10	(Xia et al., 2012)
anti-TWEAK	cGvHD	>50% reduction in proteinuria Reduced expression of MCP-1, RANTES, IP-10	(Zhao et al., 2007)
anti-Fn14	IRI1	Reduced inflammation >70% reduction in tubular damage score	(Hotta et al., 2011)
anti-TWEAK	Folic acid-induced nephropathy	Reduced inflammation and T-cell infiltration ∼30% reduction in tubular damage score ∼50% reduced serum creatinine levels	(Sanz et al., 2008; 2010)

¹IRI, ischaemia reperfusion injury.