Table 2.

Muscle atrophy in genetic models of TWEAK and Fn14

TWEAK/Fn14 model	Atrophy inducer	Effect	Ref.
TWEAK knockout	Denervation	Reduced loss in muscle mass, less reduction in muscle fibre cross section area, reduced fibrosis	(Mittal et al., 2010a)
TWEAK tg	Denervation	Enhanced loss in muscle mass, enhanced reduction in muscle fibre cross section area, more fibrosis	(Mittal et al., 2010a)
TWEAK tg	–	Reduced muscle mass, reduced muscle fibre cross section area	(Dogra et al., 2007a)
TWEAK tg	Cardiotoxin	Enhanced fibrosis	(Mittal et al., 2010b)
TWEAK knockout	Starvation	Less reduction in muscle fibre cross section area	(Paul et al., 2012)