Table 2.

Effects of 4-PBA analogues on ER stress responses

ER stress response		2-POAA-OMe	2-POAA-NO2	2-NOAA
Non-stress condition
IRE1	Kinase	→	→	↑
	Nuclease	→	→	→
ATF6		→	→	→
PERK-eIF2α		↑	↑	↑
NF-κB		→	→	→
Akt		→	→	↑
ER stress condition
IRE1	Kinase	↓	↓	↓
	Nuclease	↓	↓	↓
ATF6		↓	↓	↓
PERK-eIF2α		→	→	→
NF-κB		↓	↓	↓
Akt		↓	↓	→

↑ up-regulation.

↓ down-regulation.

→ no change.