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. 2013 Oct 1;170(4):859–870. doi: 10.1111/bph.12325

Figure 1.

Figure 1

Effects of 8-OH-DPAT (0.5 mg·kg−1) injected subcutaneously 15 min before training on fear-conditioned heart rate changes (ΔHR). Mice were subjected to either paired CS/US or CS separated from US by a 30 s trace interval during training. Heart rate was determined during the retention test in the home cage 24 h after training. ΔHR denotes changes from baseline values [180 s pre-CS phase; mean HR (0 bpm) = 583 ± 15 bpm]. CS1: the first 60 s of CS presentation; CSall: throughout the 180 s CS presentation; values represent means ± SEM; n = 6 per group; *P < 0.05; ***P < 0.001 versus saline control.