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Expression of IRβ (A) and phosphorylation state of PKB (B), PRAS40 (C) and AMPK (D) in basal state (black bars) or hyperinsulinaemic state (white bars) in muscle of mice-treated with vehicle or topiramate. The Western blot data were expressed as fold change compared to vehicle at basal condition. Data are represented as means ± SEM for n = 8–10, *P < 0.05 insulin versus basal. $P < 0.05 topiramate versus vehicle.
