Table 3. MIC values of triclosan for E. coli and Salmonella strains harboring fabI with and without mutation on a plasmid.
Bacteria | fabI carriage on plasmids |
MIC (µg/ml)a
|
|||||
---|---|---|---|---|---|---|---|
TRC | TRC in the presence of 0.25 x MIC PAβN | CHL | CHL in the presence of 0.25 x MIC PAβN | TET | TET in the presence of 0.25 x MIC PAβN | ||
E. coli TOP10 | 0.125 | < 0.008 | 4 | 1 | 2 | 0.5 | |
E. coli TOP10::pCR2.1 | 0.125 | < 0.008 | 4 | 1 | 2 | 0.5 | |
E. coli TOP10::pCR2.1 | fabI original | 2 | 0.125 | 4 | 1 | 2 | 0.5 |
E. coli TOP10::pCR2.1 | fabI Gly93→Val | 64 | 1 | 4 | 1 | 2 | 0.5 |
S. Livingstone 4 | 0.125 | < 0.008 | 8 | 2 | 2 | 0.5 | |
S. Livingstone 4::pCR2.1 | fabI original | 2 | 0.5 | 8 | 2 | 2 | 0.5 |
S. Livingstone 4::pCR2.1 | fabI Gly93→Val | 64 | 1 | 8 | 2 | 2 | 0.5 |
S. Typhimurium LT2 | 0.25 | < 0.008 | 8 | 1 | 1 | 0.5 | |
S. Typhimurium LT 2::pCR2.1 | fabI original | 4 | 0.25 | 8 | 1 | 1 | 0.5 |
S. Typhimurium LT 2::pCR2.1 | fabI Gly93→Val | 64 | 4 | 8 | 1 | 1 | 0.5 |
a CHL = chloramphenicol; TET = tetracycline; TRC = triclosan; PAβN = Phe-Arg-β-naphthylamide