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. 2013 Oct 18;8(10):e77177. doi: 10.1371/journal.pone.0077177

Figure 1. Patients with CRS have impaired NK cell functions.

Figure 1

PBLs from the controls (N, n = 19) or patients with CRS (n = 18) were incubated with or without sensitive target cells. (A, B) Degranulation of NK cells, as measured by cell-surface expression of CD107a. (C-F) Cytokine production of NK cells, as measured by intracellular expression of IFN-γ (C, D) and TNF-α (E, F). (A, C, E) Representative FACS profiles showing the percentages of CD107a+ NK cells (A), IFN-γ+ NK cells (C) and TNF-α+ NK cells (E). (B, D, F) Summary graphs of the statistical dot plots showing the expression of CD107a (B), IFN-γ (D) or TNF-α (F) by NK cells. Horizontal bars indicate the medians. Statistical differences between the groups were evaluated with the nonparametric Mann-Whitney U test. *P<0.05; **P<0.005; ***P<0.001.