Table 5. Histopathological analysis (most common lesion) of individual prostate lobes in control, finasteride, and dutasteride groups.
|
PIN
|
Adenocarcinoma
|
Prostate cancer
|
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
n
|
LG | MG |
HG
|
WD | MD |
PD
|
(WD-PD) | |||||
Anterior prostate | ||||||||||||
Control | 32 | 44%a | 20% | 20%a | 0% | 0% | 16%a | 16%a | ||||
Pre-Finasteride | 30 | 56%a | 22% | 3%a,b | 0% | 0% | 19%a | 19%a | ||||
Post-Finasteride | 29 | 50%a | 29% | 5%a,b | 0% | 0% | 16%a | 16%a | ||||
Pre-Dutasteride | 32 | 76%b | 16% | 0%b | 0% | 0% | 8%b | 8%b | ||||
Post-Dutasteride | 33 | 79%b | 14% | 0%b | 0% | 0% | 8%b | 8%b | ||||
Dorsal prostate | ||||||||||||
Control | 32 | 5%a | 59%a | 28%a | 0% | 0% | 8%a | 8%a | ||||
Pre-Finasteride | 29 | 55%b | 19%b,c | 0%b | 0% | 0% | 26%b | 26%b | ||||
Post-Finasteride | 31 | 33%c | 44%a,d | 2%b | 0% | 0% | 21%b | 21%b | ||||
Pre-Dutasteride | 31 | 73%b | 6%c | 0%b | 0% | 0% | 21%b | 21%b | ||||
Post-Dutasteride | 33 | 57%b | 31%b,d | 0%b | 0% | 0% | 12%a | 12%a | ||||
Lateral prostate | ||||||||||||
Control | 28 | 10%a | 70%a | 7%a | 0% | 0% | 14%a | 14%a | ||||
Pre-Finasteride | 30 | 52%b | 22%b | 0%b | 0% | 0% | 27%b | 27%b | ||||
Post-Finasteride | 30 | 47%b | 25%b | 2%b | 0% | 0% | 27%b | 27%b | ||||
Pre-Dutasteride | 32 | 64%c | 9%c | 0%b | 0% | 0% | 27%b | 27%b | ||||
Post-Dutasteride | 33 | 65%c | 15%b,c | 0%b | 0% | 0% | 20%c | 20%c | ||||
Ventral prostate | ||||||||||||
Control | 30 | 14%a | 68%a | 2% | 0% | 0% | 16%a | 16%a | ||||
Pre-Finasteride | 28 | 45%b | 20%b | 0% | 0% | 0% | 35%b | 35%b | ||||
Post-Finasteride | 30 | 32%c | 43%c | 0% | 0% | 0% | 25%c | 25%c,d | ||||
Pre-Dutasteride | 31 | 69%d | 2%d | 0% | 2% | 0% | 28%c | 30%b,d | ||||
Post-Dutasteride | 30 | 64%d | 17%b | 0% | 0% | 0% | 19%a | 19%a,c |
Values with different subscript letters are statistically different from one another (p<0.05).
LG = low-grade, MG = moderate-grade, HG = high-grade, PIN = prostatic intraepithelial neoplasia, WD = well-differentiated,
MD = moderately differentiated, PD = poorly differentiated.