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. 2013 Oct 18;8(10):e77738. doi: 10.1371/journal.pone.0077738

Table 5. Histopathological analysis (most common lesion) of individual prostate lobes in control, finasteride, and dutasteride groups.

1, 2.


PIN
Adenocarcinoma
Prostate cancer
n
LG MG HG
WD MD PD
(WD-PD)
Anterior prostate
Control 32 44%a 20% 20%a 0% 0% 16%a 16%a
Pre-Finasteride 30 56%a 22% 3%a,b 0% 0% 19%a 19%a
Post-Finasteride 29 50%a 29% 5%a,b 0% 0% 16%a 16%a
Pre-Dutasteride 32 76%b 16% 0%b 0% 0% 8%b 8%b
Post-Dutasteride 33 79%b 14% 0%b 0% 0% 8%b 8%b
Dorsal prostate
Control 32 5%a 59%a 28%a 0% 0% 8%a 8%a
Pre-Finasteride 29 55%b 19%b,c 0%b 0% 0% 26%b 26%b
Post-Finasteride 31 33%c 44%a,d 2%b 0% 0% 21%b 21%b
Pre-Dutasteride 31 73%b 6%c 0%b 0% 0% 21%b 21%b
Post-Dutasteride 33 57%b 31%b,d 0%b 0% 0% 12%a 12%a
Lateral prostate
Control 28 10%a 70%a 7%a 0% 0% 14%a 14%a
Pre-Finasteride 30 52%b 22%b 0%b 0% 0% 27%b 27%b
Post-Finasteride 30 47%b 25%b 2%b 0% 0% 27%b 27%b
Pre-Dutasteride 32 64%c 9%c 0%b 0% 0% 27%b 27%b
Post-Dutasteride 33 65%c 15%b,c 0%b 0% 0% 20%c 20%c
Ventral prostate
Control 30 14%a 68%a 2% 0% 0% 16%a 16%a
Pre-Finasteride 28 45%b 20%b 0% 0% 0% 35%b 35%b
Post-Finasteride 30 32%c 43%c 0% 0% 0% 25%c 25%c,d
Pre-Dutasteride 31 69%d 2%d 0% 2% 0% 28%c 30%b,d
Post-Dutasteride 30 64%d 17%b 0% 0% 0% 19%a 19%a,c
1

Values with different subscript letters are statistically different from one another (p<0.05).

2

LG = low-grade, MG = moderate-grade, HG = high-grade, PIN = prostatic intraepithelial neoplasia, WD = well-differentiated,

MD = moderately differentiated, PD = poorly differentiated.