Figure 2.

Mathematical representation of the proposed microfluidic device using a discrete fluidic circuit model. The fluidic circuit was developed using fluidic resistances (R_a, R_b, R_c, R_d), membrane compliance (C_f) owing to the half-circular chamber, and flow rates (Q_Blood, Q_PBS). To evaluate the effect of membrane compliance on the flow stabilization, the flow rate of blood was periodically delivered into the microfluidic device as Q_Blood = Q_α + Q_β sin (2πt/T). Here, T indicates the period of blood flow rate. However, the PBS solution was supplied at a constant flow rate as Q_PBS.