Table 1.

Smoking Metabolism Genes: SNP Location, Alleles and Ethnic Frequencies^a

Xenobiotic phase	Gene	SNP	Base pair no.	Allelesb	Locationc	Typed	cDNA change	Protein change	MAF	HCFe
I	CYP1A1 15q22–24 5.99kb	rs2470893	72806502	G/A	U	–	–	–	0.30	0.13
		rs1048943	72800038	A/G	E	M	1384A>G	Ile462Val	0.04	0.35
		rs1456432	72790104	G/A	D	–	–	–	0.16	0.44
	CYP1A2 15q22-qter 7.76kb	rs2472299	72820453	G/A	U	–	–	–	0.28	0.27
		rs2470890	72834479	C/T	E7	S	1548T>C	Asn516Asn	0.37	0.68
		rs11854147	72839824	C/T	D	–	–	–	0.33	0.61
	CYP1B1 2p22-p21 8.55kb	rs4646429	38160439	A/G	U	–	–	–	0.32	0.31
		rs10012	38155894	G/C	E2	M	142C>G	Arg48Gly	0.32	0.33
		rs1056836	38151707	G/C	E3	M	1294C>G	Leu432Val	0.42	0.25
		rs163084	38144420	T/C	D	–	–	–	0.20	0.14
	CYP2A6 19q13.2 6.90kb	rs4105144	46050464	C/T	U	–	–	–	0.32	0.25
		rs7250713	46047035	C/G	I2	–	–	–	0.40	0.34
		rs7246742	46037235	G/T	D	–	–	–	0.13	0.18
	EPHX1 1q42.1 20.29kb	rs2854450	224079200	C/T	U	–	–	–	0.20	0.18
		rs1051740	224086256	T/C	E3	M	337T>C	Tyr113His	0.30	0.41
		rs2234922	224093029	A/G	E4	M	416A>G	His139Arg	0.17	0.08
		rs360063	224102932	G/A	D	–	–	–	0.44	0.48
II	NAT28p23.1-p21.3 9.97kb	rs1041983	18302075	C/T	E2	S	282C>T	Tyr94Tyr	0.33	0.31
		rs1801280	18302134	T/C	E2	M	341T>C	Ile114Thr	0.44	0.32
		rs1799929	18302274	C/T	E2	S	481C>T	Leu161Leu	0.42	0.32
		rs1799930	18302383	G/A	E2	M	590G>A	Arg197Gln	0.30	0.18
		rs1799931	18302650	G/A	E2	M	857G>A	Gly286Glu	0.04	0.13
	GSTM1			WT/null	–	Null	–	Null	0.47	0.56
	GSTT1			WT/null	–	Null	–	Null	0.20	0.13

^aHCF = Hispanic corresponding frequency to NHW minor allele; MAF = minor allele frequency in non-Hispanic white sample; WT = wild-type.

^bAncestral allele/alternate allele.

^cU = upstream, E = exon, I = intron, D = downstream.

^dType of mutation: M = missense; S = synonymous.

^eValues in bold = HCF significantly different from MAF [p < 0.01].