Redox modulation of ASIC currents in neurons from ASIC1−/− or ASIC2−/− mice. A, B, Representative traces and summary data showing the modulation of ASIC currents by the reducing or the oxidizing agents in cortical neurons from C57BL/6 mice, a wild-type control for the ASIC knock-out mice; n = 5–6. C, D, Representative traces and summary data showing a lack of modulation of ASIC currents in ASIC1−/− neurons by either reducing or oxidizing agents; n = 8–9. E, F, Representative traces and summary data showing the effect of redox reagents on ASIC currents in ASIC2−/− neurons; n = 7–12; *p < 0.05; **p < 0.01.