Relationships between rates of change in MAP (RcMAP) and p-tau181 (Rcp-tau181) (a), rates of change in MAP and episodic verbal memory (Rcepisodic memory) (b), rates of change in episodic verbal memory and p-tau181 (c), rates of change change in p-tau181 and hippocampal volume (RcHippocampal volume) (d). Solid circles and solid lines – subjects with HTN. Diamonds and dashed lines - subjects without HTN. Units in the scales represent units per year: for p-tau pg/mL/year, for MAP mmHg/year, for episodic memory z-score unit/year, for hippocampal atrophy % of intracranial volume/year.