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. Author manuscript; available in PMC: 2013 Oct 19.
Published in final edited form as: Vitam Horm. 2012;88:141–171. doi: 10.1016/B978-0-12-394622-5.00007-9

Figure 1. Schematic representation of Glis1-3 protein structure.

Figure 1

The primary structure of Glis proteins and their identified domains are shown (ZFD = zinc finger domain; TAD = transactivation domain; NCR = N-terminal conserved region that is shared with GLI proteins). Bold lines represent regions within Glis proteins required for their interaction with C-terminal binding protein 1 (CtBP1); p120 catenin (p120ctn), Suppressor of Fused (SuFu), Cullin 3 (Cul3), and transcriptional coactivator with PDZ-binding motif (Taz) as indicated. The potential phosphorylation site, Serine245, is specified in Glis2. Numbers indicate the amino acid position.