Fig. 6.

Model Building. (A) Domain organization of talin1. (B) Front view of a single modeled talin1 monomer inside the EM density. The view is identical to that shown in Fig. 5a. The individually colored domain envelopes of the rod domains and the head domain are shown as solid surfaces. The EM reconstruction is shown as a black wire mesh. A thin black line marks the symmetry axis. (C) Front view of the entire talin1 dimer. The two monomers are colored white (rod)/blue (head) and pink (rod)/red (head) respectively. (D) Front view of talin1 dimer model with heads omitted. (E) Side view of talin1 monomer model. Color scheme follows (A). (F) View turned 180° around the symmetry axis from (E) for monomer model. Color scheme as in (A). (G) Side view of dimer model in the same orientation as (F). Color scheme follows (C). (H). Bottom view of dimer model along the symmetry axis showing the dimerization helices DD and DD^* symmetric around the axis. Color scheme follows (C). (I) Top view of dimer model 180° from (H) along the symmetry axis. Color scheme follows (C). Bar represents 5 nm.