Structure activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism

. Author manuscript; available in PMC: 2013 Oct 19.

Published in final edited form as: Bioorg Med Chem Lett. 2012 Apr 13;22(11):3656–3660. doi: 10.1016/j.bmcl.2012.04.034

Scheme 3. Reactions and conditions: (a) OsO4, NMO, acetone-H2O (1:1); (b) pivaloyl chloride, NEt3, DMAP, CH2Cl2; (c) DPPA, DBU, toluene; (d) CS2, PPh3, THF; (e) 16 or 17, NEt3, CH2Cl2.