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. Author manuscript; available in PMC: 2013 Oct 19.
Published in final edited form as: Recent Results Cancer Res. 2013;194:149–175. doi: 10.1007/978-3-642-27994-2_9

Figure 3.

Figure 3

Stability of [64Cu]-DOTA-peptide analogs in human serum. Radiolabeled peptides were incubated in human serum at 37°C, and at specified time points samples were spotted on iTLC paper and developed with 0.1 M citric acid. Panel A shows the peptides in serum at t = 0 min, and all of the radiolabeled peptide remains at the bottom of the plate. By 24 h, the linear peptides α-MSH and NDP-α-MSH are degraded by the serum while the cyclic ClickMTII analogs remain intact (Panel B). Panel C graphically represents the degradation data over the 24 h time period for all peptides.