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. Author manuscript; available in PMC: 2013 Oct 19.
Published in final edited form as: Science. 2013 Mar 8;339(6124):1216–1219. doi: 10.1126/science.1231097

Fig. 4.

Fig. 4

mSIRT1-E222K–dependent effects of STACs on mitochondrial-related parameters in cells. (A) Full-length murine SIRT1 (mSIRT1) transcripts in wild-type and primary myoblasts reconstituted with wild-type mSIRT1 or mSIRT1-E222K. The SIRT1 exon 3-4 junction (SIRT1 E3-4) and 18S ribsosomal RNA, as an internal control for loading, were detected by reverse transcription polymerase chain reaction. (B and C) Effect of 25 μM resveratrol (B) or 1 μM STAC-4 (C) on mitochondrial mass and ATP in primary myoblasts; data are means ± SEM (n = 6). *P < 0.05, ** P < 0.01 (t test versus DMSO control).