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Synthesis of DPCs by a post-synthetic reductive amination strategy: (a) oxidative cleavage to unmask the reactive aldehyde moiety on the 7-deaza-7-(2,3-dihydroxypropyl)-guanine of the synthetic oligomer, (b) reaction of an amino group on the protein with the aldehyde on the DNA to form a Schiff base, (c) reduction of the imine to form a stable amine linkage.
