Table 1.

Schedule of Testing

Time (min)	Procedure
−90	Confirmation of abstinence from caffeine, alcohol, drugs, medications
	Vital signs
	Urine drug screen, urine pregnancy test
	Placement of intravenous lines
−60	Behavioral assessments:   PANSS   CADSS   VAS for “high,” “calm and relaxed,” and “anxiety”
	Blood sampling: Δ-9-THC and THC-COOH
	Vital signs
0	IV Δ-9-THC (0, 2.5, or 5 mg) over 2 min
+10	Vital signs: every 2 min (10 min) followed by every 5 min (20 min) and then every 10 min
	Behavioral assessments:   PANSS   CADSS   VAS for “high,” “calm and relaxed,” and “anxiety”
	Blood sampling: Δ-9-THC and THC-COOH
+30	Learning (immediate recall): HVLT
+45	Distractibility and vigilance: Gordon Box
+60	Delayed Free, cued, and recognition recall: HVLT
+80	Behavioral assessments:   PANSS   CADSS   VAS for “high,” “calm and relaxed,” and “anxiety”
	Blood sampling: Δ-9-THC and THC-COOH
+140	Blood sampling: Δ-9-THC and THC-COOH
+200	Behavioral assessments:   PANSS   CADSS   VAS for “high,” “calm and relaxed,” and “anxiety”
	Blood sampling: Δ-9-THC and THC-COOH
End of each day	Field sobriety test, Mini-Mental State Examination, vital signs, physician evaluation
Last day	Exit interview
Months 1, 3, 6	Assessment of cannabis use, desire, craving
	Assessment for emergence of new psychiatric or medical problems

PANSS: Positive and Negative Syndrome Scale; CADSS: Clinician-Administered Dissociative Symptoms Scale; VAS: Visual Analog Scale; Δ-9-THC: Δ-9-tetrahydrocannibinol; THC-COOH: 11-nor-Δ-9-THC-9-COOH; HVLT: Hopkins Verbal Learning Test.