Table 2. Duration of each line of treatment.
| TRD episodesa(N = 3,134) | Non-TRD episodes (with at least one ADAP prescription)(N = 44,520) | p (Ho: MT = MN; H1: MT<>MN) | |||||
| Line of Treatment | N | Median duration(In days) | Mean duration(In days) | N | Median duration(In days) | Mean duration(In days) | Comparing Mean Duration(In days) |
| LOT 1 | 3,134 | 93 (55–223) | 183 | 44,520 | 114 (38–322) | 257 | <0.001 |
| LOT 2 | 3,134 | 69 (48–147) | 139 | 9,952 | 83 (42–204) | 192 | <0.001 |
| LOT 3 | 3,134 | 72 (45–183) | 157 | 4,341 | 141 (62–348) | 267 | <0.001 |
| LOT 4 | 2,406 | 84 (47–196) | 171 | 1,512 | 98 (53–252) | 210 | <0.001 |
| LOT 5 | 1,651 | 85 (49–190) | 167 | 763 | 114 (56–275) | 222 | <0.001 |
| LOT 6 | 1,142 | 85 (49–165) | 154 | 333 | 95 (59–228) | 188 | 0.01 |
| LOT 7 | 794 | 83 (46–166) | 161 | 185 | 99 (56–220) | 194 | 0.04 |
| LOT 8 | 545 | 87 (45–191) | 157 | 99 | 106 (49–251) | 201 | 0.05 |
| LOT 9 | 379 | 79 (45–170) | 144 | 49 | 91 (59–148) | 154 | 0.71 |
| LOT 10 | 264 | 79 (46–151) | 151 | 26 | 79 (51–237) | 184 | 0.48 |
Figures in brackets represent lower and upper quartile limits.
Abbreviations: ADAP: Antidepressant and antipsychotic/antimanic drugs; p = p-value; H0 = Null Hypothesis, H1 = Alternative Hypothesis; MT = the average duration of a LOT in TRD episodes, MN = the average duration of a LOT in non-TRD episodes; LOT = Line of therapy.
a
An episode will have at least 3 lines of treatment to qualify as TRD, based on the definition stated in the Methods section.