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. 2013 Oct 18;8(10):e76882. doi: 10.1371/journal.pone.0076882

Table 5. Regimen usage by line of treatment in non-TRD episodes.

Line of treatment
Regimen 1 2 3 4 5 6 7 8 9 10
SSRI only 64% 35% 49% 29% 40% 27% 35% 32% 31% 38%
Atypical ADs only 12% 8% 12% 9% 12% 7% 12% 12% 12% 8%
SNRI only 10% 9% 13% 8% 12% 9% 11% 3% 14% 8%
AD–Others only 5% 6% 6% 7% 6% 7% 8% 12% 6% 12%
SSRI & Other ADs 3% 10% 6% 13% 10% 17% 14% 11% 8% 15%
SSRI & Atypical AD 2% 12% 4% 13% 5% 12% 6% 4% 8%
SSRI & SNRI 0% 4% 1% 3% 2% 3% 1% 2%
SSRI & AP 1% 3% 1% 4% 1% 4% 3% 5% 6% 8%
N (Episodes) 44,520 9,952 4,341 1,512 763 333 185 99 49 26

Note: ‘AD – Others’ includes alpha-2 receptor antagonists (tetracyclics), modified cyclics, tricyclic agents; Atypical AD includes miscellaneous antidepressants, chiefly bupropion;

AP (Antipsychotics) includes benzisoxazoles, butyrophenones, dibenzapines, dihydroindolones, phenothiazines, quinolinone derivatives, thioxanthenes.

Abbreviations: SSRI: Selective serotonin reuptake inhibitor;AD: Antidepressant; SNRI: Serotonin norepinephrine reuptake inhibitors.